How long does Ambien work in the body? After intaking Ambien 10 mg, it starts to work within 30 minutes. Within this time duration, it hits its peak blood concentration. It takes effect very quickly. The half life, or the time it takes for medication to decrease by half, is 1.5 hours. However, the effects of the medication may last up to 8 hours after use. Order here - https://getyourpharmacy.com/product-...ambien-online/