Disinfectant

[Barbecueboy]

Give it a couple days. We've seen people die from ingesting chloroquine because of Trump.

The folks ingesting it without a Drs consent or advisement are the same folks ingesting the tide pods.....and for all intent and purposes, those are your peeps.

[mcarter815]

https://jamanetwork.com/journals/jam...tm_term=042420

Key Points
Question: How safe and effective are 2 different regimens of chloroquine diphosphate in the treatment of severe coronavirus disease 2019 (COVID-19)?

Findings: In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned interim analysis recommended by an independent data safety and monitoring board found that a higher dosage of chloroquine diphosphate for 10 days was associated with more toxic effects and lethality, particularly affecting QTc interval prolongation. The limited sample size did not allow the study to show any benefit overall regarding treatment efficacy.

Meaning: The preliminary findings from the CloroCovid-19 trial suggest that higher dosage of chloroquine should not be recommended for the treatment of severe COVID-19, especially among patients also receiving azithromycin and oseltamivir, because of safety concerns regarding QTc interval prolongation and increased lethality.

Abstract
Importance: There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug.

Objective: To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID-19.

Design, Setting, and Participants: This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon.

Interventions: Patients were allocated to receive high-dosage CQ (ie, 600 mg CQ twice daily for 10 days) or low-dosage CQ (ie, 450 mg twice daily on day 1 and once daily for 4 days).

Main Outcomes and Measures: Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4.

Results: Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%] to high-dosage group and 40 [49.4%] to low-dosage group). Enrolled patients had a mean (SD) age of 51.1 (13.9) years, and most (60 [75.3%]) were men. Older age (mean [SD] age, 54.7 [13.7] years vs 47.4 [13.3] years) and more heart disease (5 of 28 [17.9%] vs 0) were seen in the high-dose group. Viral RNA was detected in 31 of 40 (77.5%) and 31 of 41 (75.6%) patients in the low-dosage and high-dosage groups, respectively. Lethality until day 13 was 39.0% in the high-dosage group (16 of 41) and 15.0% in the low-dosage group (6 of 40). The high-dosage group presented more instance of QTc interval greater than 500 milliseconds (7 of 37 [18.9%]) compared with the low-dosage group (4 of 36 [11.1%]). Respiratory secretion at day 4 was negative in only 6 of 27 patients (22.2%).

Conclusions and Relevance: The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir. These findings cannot be extrapolated to patients with nonsevere COVID-19.

Trial Registration: ClinicalTrials.gov Identifier: NCT04323527

[Barbecueboy]

So they aren't real sure......like everyone else.

[mcarter815]

It was risky enough that they stopped the study early.

[ss12]

i was so moved by our president,s suggestion that i just drank a bottle of lysol and a quart of clorox and chased it with a 6 pack of corona,s , just for good measure , i feel better than ever , Mcfarter , ss and kid , you guys should really try it...but i guess yall will wait till CNN approves it , right? yall do entertain me though , but it is sad what all of you have become , Kid , do really believe the president meant some one should inject themselves with lysol???? come on man , you know what he meant , he plainly said stuff like this was to be handled by med professionals , that he was NO doctor and could not say for sure , and i guarantee you none of his "gulable followers " are that stupid , now some on the far right might try it just to create more slander for the pres and give you lib,s something to crow about , who knows ......

The problem is everybody knows what he meant. King Donald Dumb is losing all of his credibility. Everybody is realizing how dumb he really is. The only citizens that still have faith in him is his gullible followers and I don't know how much longer that will last. FF his gullible followers are obviously that stupid. A man died after the president indicated that Chloroquine was a treatment for covid-19.

https://www.forbes.com/sites/tarahae.../#791b88ec72e9

[dirtMAN007]

the problem is everybody knows what he meant. King donald dumb is losing all of his credibility. Everybody is realizing how dumb he really is. The only citizens that still have faith in him is his gullible followers and i don't know how much longer that will last. Ff his gullible followers are obviously that stupid. A man died after the president indicated that chloroquine was a treatment for covid-19.

https://www.forbes.com/sites/tarahae.../#791b88ec72e9

you have no proof he is losing anything !!!!! The only ones losing theri sh!t are the people like you who cannot hurt the greatest president ever no matter what lies you tell or how you spin his words !!! November cannot come fast enough you will see who he lost and who he gained ! So until then just stfu !!!

[WildBill32]

Trump is doing a great job as always. Can anybody really believe that Sleepy Joe Biden has a chance to beat Trump. He is not even sure what day it is or even what State he is in. Lol I guess that's the best the Dems have to offer. Lmao...

[Barbecueboy]

The problem is everybody knows what he meant. King Donald Dumb is losing all of his credibility. Everybody is realizing how dumb he really is. The only citizens that still have faith in him is his gullible followers and I don't know how much longer that will last. FF his gullible followers are obviously that stupid. A man died after the president indicated that Chloroquine was a treatment for covid-19.

https://www.forbes.com/sites/tarahae.../#791b88ec72e9

Quoting Forbes now? If trump is so dumb and unbelievable like you claim then wouldnt the guy that took the chloroquine ( a version of quinine, aka what's used in tonic water) without a doctor close by to monitor his self medication be the dumb one?

I mean if nobody believes trump anyway then why would someone take his advice??

You guys step on yer docks more than a seagull looking for dried shrimp.

[mcarter815]

Quoting Forbes now? If trump is so dumb and unbelievable like you claim then wouldnt the guy that took the chloroquine ( a version of quinine, aka what's used in tonic water) without a doctor close by to monitor his self medication be the dumb one?

I mean if nobody believes trump anyway then why would someone take his advice??

You guys step on yer docks more than a seagull looking for dried shrimp.

Nobody smart believes Trump. Unfortunately, Trump has a lot of gullible fans.

[dirtMAN007]

nobody smart believes trump. Unfortunately, trump has a lot of gullible fans.

wow ! That says a lot about you and your libterd anti american trump hating cohorts !!!!!!

[ss12]

There are multiple articles of the man dying from using chloroquine after taking King Donald Dumb advice that its treats covid-19. The dumb person would be the dumb president for misleading the citizens with false information. The president should be giving out truthful and proven information. By now everybody should realized that the President can't tell the truth. King Donald Dumb is nothing but a fraud.

[Barbecueboy]

Nobody smart believes Trump. Unfortunately, Trump has a lot of gullible fans.

Sure, all the smart ones voted for Hillary......lmao.

Everybody believes that, right?

[Barbecueboy]

There are multiple articles of the man dying from using chloroquine after taking King Donald Dumb advice that its treats covid-19. The dumb person would be the dumb president for misleading the citizens with false information. The president should be giving out truthful and proven information. By now everybody should realized that the President can't tell the truth. King Donald Dumb is nothing but a fraud.

So using that logic and if by now everybody should realize the president doesn't tell the truth , then the guy that self medicated himself despite knowing that is an idiot.

Wouldn't you agree?

[mcarter815]

Sure, all the smart ones voted for Hillary......lmao.

Everybody believes that, right?

No, all I said is that nobody smart believes Trump.

[ss12]

So using that logic and if by now everybody should realize the president doesn't tell the truth , then the guy that self medicated himself despite knowing that is an idiot.

Wouldn't you agree?

The problem is his followers believe every things he says as being factual. Again gullible fools for believing him in the 1st place. I taken it you still believe in him the way you keep defending him.

"then the guy that self medicated himself despite knowing that is an idiot." Was that a mistake?

Did you mean Then the guy that self medicated himself knowing that the president is an idiot?